Ive used it on a couple of mine, and I also have some friends who have done it. The most common practical starting dosage for many cats is of the 5.4mg tablet, or 2.7mg. Unless my vet (and an unaffiliated nutritionist) I consulted are wrong-- I was told that allergy serum is only possible/effective for some allergies and a lot of food-based ones are not on the list. Gadeyne C, Little P, King VL, et al. The dose range is very strict, I do not recommend going above the recommended dose due to immune suppression, below the range and it doesn't seem to work in most cases. All dogs itch sometimes, but when you notice it happening more and more, it could be a sign of a medical condition. Six adult horses with a mean weight of 528 kg were . Pre-slaughter withdrawal time is 14 days following the last dose. However, these studies have shown that oclacitinib can be a good alternative therapy to treat feline pruritus, especially for patients that do not respond to other treatments or do not tolerate steroids. Treatment success in three Andean bears (Tremarctos ornatus) with alopecia syndrome using Oclacitinib maleate (Apoquel). In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days. Apoquel comes in tablet form only. Pasture-associated equine asthma is most prevalent during the summer in the southeastern U.S. but has been reported worldwide. Pollen and other plant-based aeroallergens are the source of their distress, and they fare much better inside a well-ventilated barn. These reports suggest the potential use of oclacitinib in other diseases; however, it cannot be stressed enough that the use of oclacitinib in these diseases is an off-label use. Posted by Lucile Vigouroux | May 4, 2022 | Article, Diseases and Conditions, Farm and Barn, Hives & Skin Allergies, Horse Care, Medications, Nutrition, Seasonal Care, Skin Problems. Copyright 2023 Today's Veterinary Practice Web DesignbyPHOS Creative. Dexamethasone is a synthetic corticosteroid hormone used to manage inflammation in diseases or conditions in which the immune system has a significant role. has been administered by veterinarians to help horses of . It's touted as being "a fast-acting and safe treatment for the control of acute and chronic canine pruritus." Pruritus means itching. Since some horses have both "types" of asthma, you may need to try a stall without bedding, or experiment with different types of bedding. Some states restrict the information we may provide about controlled substances. Unlike steroids, the drug has minimal impact on the immune system. The dosage for dogs 10-14.9 lbs is of a 5.4 mg tablet twice daily. Many of these cytokines bind to cytokine receptors that have JAK enzymes associated with their cytoplasmic portion. Having allergy tested 3 horses you can get a serum for some allergens but not all. Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. Speak to yourveterinarian in an emergency. Acupuncture: It appears that some horses with Equine Asthma can benefit from acupuncture to help with breathing function. These might include antihistamines such as cetirizine, which you can buy over the counter as Zyrtec from any drug store or pharmacy, or hydroxyzine, which requires a veterinary prescription. 6. I have not tried to go less than that. 23. Aymeric E, Bensignor E. A case of presumed autoimmune subepidermal blistering dermatosis treated with oclacitinib. Haugh IM, Watson IT, Menter MA. At that point, the treatment can be changed to oclacitinib. Apoquel is used to treat and control itching and inflammation in dogs resulting from a variety of causes, including environmental allergies, food allergies, flea allergy, and contact allergies. You can use a nebulizer, an inhaler, or a single-nostril aerosol chamber. Like most treatments, this medication will not be successful in every horse, but if it does work, it avoids the risks associated with steroids. 19. This encourages the natural drainage of irritants, allergens, and bacteria from the airways.. 2. Dosage and administration For oral use. Cosgrove SB, Wren JA, Cleaver DM, et al. 16. Comparing Apoquel and Cytopoint. I havent noticed any abnormal side effects. Specifically, studies in cats have used the following dosage: Initially, doses ranging from 0.4 to 1.2 mg/kg body weight, twice daily, for 24-28 days. All product and company names are trademarks or registered trademarks of their respective holders. 28. Adverse events were reported in less than 5% of dogs, including urinary tract infection, vomiting, otitis, pyoderma, and diarrhea. So I think cost becomes dependent on that. Adding an update here in case its helpful for others. 9. The Janus kinases (Jaks). Treatment success in three Andean bears (Tremarctos ornatus) with alopecia syndrome using Oclacitinib maleate (Apoquel). Vet Dermatol 2013;24:48-e12. Apoquel has been a game changer, however. The bodys largest organ, the skin serves as the immune systems first protective barrier. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. Not really cheap any way you shake it, but considering that she was on zyretc, dex, smarthbreathe ultra, respi-free previously. 28. The Feed: One of the most common recommendations for managing Equine Asthma has always been to stop feeding hay. Dawn M. Cleaver, DVM Associate Director, Regulatory Affairs Thereafter the dose should be reduced to once daily for maintenance. The powerful network of cells and antibodies known as the immune system can recognize dangerous invaders and disarm them before they hurt the host. Until recently, glucocorticoids (systemic and/or topical) and cyclosporine have been considered the most effective symptomatic treatment options to manage atopic dermatitis.5 Oclacitinib is now also an effective option (BOX 1). Gonzales AJ, Bowman JW, Fici GJ, et al. . New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. Since oclacitinib is a rather weak anti-inflammatory drug, it was suggested that remission of active moderate to severe atopic dermatitis be induced with a course of a broad inflammation-targeting drug, such as a short-acting glucocorticoid, until clinical signs become mild. With an online account, access our extensive formulary or over 40,000 unique items - 24 hours a day, 7 days a week. This site is for US animal healthcare professionals. This gives you the total number of milligrams for the dose for your horse. Avoid storing hay in the same barn as sensitive horses, since hay particles and spores can be irritating, even from a distance and even if they are not visible in the air. Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Nevertheless, these data should be taken with caution, and only as an approximation, because there is no basic information on the . She adds, however, that some horses allergy signs are so dramatic that corticosteroids are the most logical choice, at least initially. Qualifies for Zoetis Petcare Rewards! Fortunately, these side effects are relatively uncommon. These are known as allergy shots. APOQUEL may be administered with or without food. Apoquel reduces dog itch, and also decreases inflammation, redness, or swelling of the skinso your dog feels better as quickly as possible What is Apoquel Tablet? Since it became available in 2014, several clinical studies have confirmed its antipruritic effect not only in dogs but also in cats, as well as in other immune-mediated diseases. Excitement rather than lethargy can occur occasionally, especially in cats. Horse dosing is 5 pills. Ortalda C, Noli C, Colombo S, et al. Why were losing our horse doctors and how to begin solving the problem. Gonzales AJ, Humphrey WR, Messamore JE, et al. I have noticed that in general she is more comfortable on cooler days. While efficacy was comparable to that observed in the previous studies, significant positive effects on the dogs quality of life were observed in >91.5% of cases after 630 days. The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Stay current with the latest techniques and information sign up below to start your FREE Todays Veterinary Practice subscription today. Then, doses ranging from 0.4 to 1.2 mg/kg body weight once daily. Many allergens can cause skin reactions. Interestingly, the results suggest that oclacitinib has immunosuppressive properties, but only at a higher dosage than that approved on the label. Insect and pollen season is here. I draw up a little calendar for them each month to help keep track. Apoquel Oclacitinib Used for Pet Meds MORE expand_more savings GoodRx lowest price $75.90 (Save -22%) local_offer Avg retail price $62.49 medication Availability Brand only Get 20% off your first order with code GOODRX20 Shop Apoquel at America's #1 Pet Pharmacy for the best pet prescription medications online! Fukuyama T, Ganchingco JR, Bumer W. Demonstration of rebound phenomenon following abrupt withdrawal of the JAK1 inhibitor oclacitinib. The drug targets pro-inflammatory proteins, called cytokines, responsible for itching and inflammation, relieving signs of skin allergies. 13. The pharmacokinetics of oclacitinib maleate, a Janus kinase inhibitor, in the dog. to 14 days, and then administered once daily for maintenance therapy. Each dosage is sold per tablet, in 20 count, or 100 count bottles. Oclacitinib is available in 3 different tablet sizes: 3.6, 5.4, and 16 mg. Skin allergies can also cause pruritus (itching) and associated hair loss. Ordering your pet's prescription drugs from Wedgewood Pharmacy is safe, and convenient. But the immune system is not a perfect one. Rectal Prolapse in Dogs and Cats. Drake GJ, Nuttall T, Lpez J, et al. Cosgrove SB, Wren JA, Cleaver DM, et al. After remission, some dogs were well controlled with a tapered dose of oclacitinib (0.2 to 0.5 mg/kg q24h), but some needed a higher dose (0.6 to 0.7 mg/kg q12h) to avoid relapse.28,29 The exact mechanisms of oclacitinib in these diseases are unknown; however, the need for daily administration of oclacitinib indefinitely to control the disease suggests that oclacitinib plays a role in controlling the disease. Avoid giving the medicine twice daily long-term. Vet Dermatol 2016;27(Suppl 1):84 (abstract). Stay up-to-date on the latest news about your horse's health with FREE newsletters from TheHorse.com. Apoquel should be shipped with extreme caution when temperature is below 35 degrees Fahrenheit. Vet Dermatol 2014;25(6):512-518. He stayed on as a faculty member until 2013, when he decided to move back to Switzerland to open his own dermatology clinic in his hometown of Basel in 2014. The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up . The most common side effect is lethargy, dry mouth, and urinary retention. In more severe cases, Apoquel can be given twice per day. This is a new treatment option, and currently the tablets are not FDA approved for horses, only dogs. Oclacitinib (APOQUEL) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. In this study, 70% of the study population receiving oclacitinib showed improvement in pruritus compared with 75% in a group receiving methylprednisolone.18 Based on this study, a higher dose with a longer induction period seems to be the key to successfully treating feline pruritus with oclacitinib. Like most treatments, this medication will not be successful in every horse, but if it does work, it avoids the risks associated with steroids. I paid $250 for 100 pills (thats 20 5-pill doses). Sometimes it goes overboard and reacts in the face of a generally harmless substancewhich the body begins to recognize as an allergenand an allergic reaction occurs. The mare luckily didnt have a lot of food allergies and eliminating flax wasnt a big deal. I had a cat on it years ago and it was $$$$ but it was the only thing that worked for her. Collard WT, Hummel BD, Fielder AF, et al. IgE binds to cells in the body and releases inflammatory molecules. 1,2 For over 30 years, Adequan i.m. llergies can develop at any time, in any horse, and for virtually any reason. Apoquel. Several reports of successful use of oclacitinib to treat other diseases have been published. So I want to make sure she has the support she needs to acclimate to hot humid summer weather. Option 4 is an oral tablet called Apoquel. Join us as we interview leading equine researchers from the University of Kentucky, Problem Solver Series: How to Control Nuisance Birds on Horse Properties. Little PR, King VL, Davis KR, et al. Long term itch reduction. Intradermal allergy testing is the gold standard for this and involves a veterinary dermatologist subcutaneously injecting very small quantities of potential allergens into a clipped patch of the horses neck. Please select your state below. Cosgrove SB, Cleaver DM, King VL, et al. May be used with other common medications. 25. and unfortunately grass and dust are the main culprits. Previcox is an FDA-approved non-steroidal anti-inflammatory (NSAID) prescription medication used in dogs to treat pain and inflammation associated with osteoarthritis and for the control of postoperative pain and inflammation associated with soft-tissue and orthopedic surgery. 23. If you mix it in their food, ensure that your pet chews the treatment rather than swallowing it without chewing for effective results. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. The dose of Apoquel tablets is 0.18-0.27 mg/lb (0.4-0.6 mg/kg). The efficacy of oclacitinib was also compared to that of other drugs such as prednisolone and cyclosporine. Once you have the horse's symptoms under control, you can try re-introducing hay. I did not know about this, but considering Im going through apoquel at a reasonable rate this sounds like it would be worth signing up for. Meaning, if a 100lbs dog gets 16mg (1 pill), a horse does not need 160mg (10 pills). Assuming you cannot contact your vet: For hives or possible allergic airway disease (heaves), for a 1000 lb horse, give 5-10 tabs of 25mg diphenydramine crushed up and mixed in water and dosed in a syringe orally (by mouth). The biggest disadvantages are the cost, the need to acclimate the horse to having the device placed in his or her nostril, poor tolerance by some horses who dislike the device, and the uncertainty about how long your horse will be able to go without repeating the treatment. Rabies in Animals. The dosages of oclacitinib of 1 mg/kg and 2 mg/kg were chosen because the dosages used for dogs (0.4-0.6 mg/kg) were not shown to be very effective in cats [ 18 ], and the higher dosage range of 0.8-1.3 appeared to be more effective in allergic cats [ 22 ]. We have been using an inflatable fleece e-collar on her . She still has her mane this year- which is good! Old fashioned drugs like Benadryl and steroids don't work well any more. During this period, the drug is administered twice daily, with an interval of 12 hours. On the topic of simple and economical allergy management, a readily accessible ingredient that helps many horses is, Recently, we have found that latex, which is everywhere in the horses environmentembedded in riding surfaces and racetracks, for examplemay be associated with severe equine asthma, he says. Because many respiratory allergies come from the dust in hay and bedding, veterinarians generally recommend maximizing fresh-air time through turnout. Submit Office Orders & Patient Prescriptions. Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction. A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats. Pet owners should visit ZoetisPetcare.com for product info, rewards and support. Since oclacitinib is a rather weak anti-inflammatory drug, it was suggested that remission of active moderate to severe atopic dermatitis be induced with a course of a broad inflammation-targeting drug, such as a short-acting glucocorticoid, until clinical signs become mild. Serious side effects include seizures, abnormal breathing, incoordination, muscle tremors, and coma. Pruritus is a common clinical sign in allergic skin diseases. 405 HERON DRIVE SUITE 200 SWEDESBORO, NJ 08085-1749 | 2004-2023 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED. Hydroxyzine is usually given orally twice to three times daily in dogs, cats, horses and birds. Vet Dermatol 2017;28(5):485-e113. Discount Prices on Pet Supplies, Nexgard, Bravecto, Trifexis, Simparica TRIO, Apoquel, and more. 19. DERM DIALOGUE. J Vet Pharmacol Ther 2014;37(3):279-285. Powered by Discourse, best viewed with JavaScript enabled. Apoquel is an anti-itch tablet given twice daily for the first . 14. Luckily most of her allergies appear to be insect-based and she responds very well to the serum for that. Six adult horses with a mean weight of 528 kg were administered a single dose of 0.5 mg/kg oclacitinib maleate. Cost is about $10 per day for the first few weeks of treatment, and may decrease to around $5 per day depending on the horses response. Vet Dermatol Before your vet administers immunotherapy, though, you must identify your horses respiratory and skin allergies. She then completed a 1-year rotating small animal internship in Massachusetts followed by a 3-year veterinary dermatology residency in Georgia. Veterinarians are especially wary of administering corticosteroids to allergic horses that suffer from pituitary pars intermedia dysfunction, insulin dysregulation, and/or equine metabolic syndrome, because these conditions are also risk factors for laminitis. It is no surprise we see this omega-3-rich plant with anti-inflammatory and antioxidative properties in many skin and allergy supplements. Option 4 is an oral tablet called Apoquel. . Aymeric E, Bensignor E. A case of presumed autoimmune subepidermal blistering dermatosis treated with oclacitinib. Im currently struggling with my horses allergies. We have had variable results with this treatmet. The drug targets pro-inflammatory proteins, called cytokines, responsible for itching and inflammation, relieving signs of skin allergies. In a 3-week trial, the combination of oclacitinib and cyclosporine did not show an increased risk for adverse effects. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Weve also been able to start rehabbing back into work. Most common side effects are vomiting and diarrhea. This content is intended for counseling purposes only. In cats, this medication can cause excitement rather than sedation. See how Apoquel works differently from steroids and cyclosporines, Discover how Apoquel can relieve allergic itch through an 8-week food trial, Hear from your peers about why Apoquel is their first choice for allergic itch relief, Explore the United States of Apoquel to see how Apoquel has benefited veterinarians in your region, Hear real stories of allergic itch relief from pet owners, See how Zoetis Petcare Rewards can benefit your practice, Informational resources for you to download and utilize within your practice, Provide additional information about Apoquel to pet owners with these resources, Continue therapy once daily (SID) thereafter for maintenance. Fukuyama T, Ganchingco JR, Bumer W. Demonstration of rebound phenomenon following abrupt withdrawal of the JAK1 inhibitor oclacitinib. Haugh IM, Watson IT, Menter MA. The efficacy and safety of oclacitinib have been assessed in various studies. Unlike steroids, the drug has minimal impact on the immune system.